Three goals in the first and one in the second half ensured the Africans were well beaten at the Stade de la Rabine in Vannes.
Ghana went behind as early 21st minute after Aniek Nouwen connected with a corner to hit the back of the net.
Having netted in their opener, Fenna Kalma made no mistake when put through by the Victoria Pelova, before converting with superbly taken volley to see her move joint-top of the scoring charts
Netherlands sealed the game in the 80th minute when Victoria Pelova slotted home at the near post after a beautiful one-two play with a teammate.
This defeat means the Black Queens are mathematically out of the tournament with a game to spare as they will play New Zealand in their last group game on August 12.